Magnetic resonance imaging of brain iron in health and disease
Identifieur interne : 002313 ( Main/Exploration ); précédent : 002312; suivant : 002314Magnetic resonance imaging of brain iron in health and disease
Auteurs : Josef Vymazal [États-Unis] ; Rodney A. Brooks [États-Unis] ; Nicholas Patronas [États-Unis] ; Milan Hajek [États-Unis] ; Jeff W. M. Bulte [États-Unis] ; Giovanni Di Chiro [États-Unis]Source :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1995.
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Abstract
Brain iron is a major contributor to magnetic resonance imaging (MRI) contrast in normal gray matter, and its role in the pathogenesis of different neurological disorders has also become apparent. Non-heme brain iron is present in the brain mainly in the form of ferritin. The unique magnetic properties of ferritin determine different signal changes on both T1- and T2-weighted images, and the T2 relaxation rates have a linear dependence on applied field strength. This finding is typical for ferric oxyhydroxide cores. The resulting T2-shortening also depends on echo-spacing used in the imaging sequence as well as on the water diffusion coefficient and the size of the ferritin cluster. Quantitation of non-heme brain iron by MRI aids in the diagnosis and monitoring of different neurological diseases.
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DOI: 10.1016/0022-510X(95)00204-F
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Bulte</name></author><author><name sortKey="Di Chiro, Giovanni" sort="Di Chiro, Giovanni" uniqKey="Di Chiro G" first="Giovanni" last="Di Chiro">Giovanni Di Chiro</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DCC86673A5325FCCE998360614B8849CF892FA31</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1016/0022-510X(95)00204-F</idno><idno type="url">https://api.istex.fr/document/DCC86673A5325FCCE998360614B8849CF892FA31/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002A49</idno><idno type="wicri:Area/Main/Curation">002691</idno><idno type="wicri:Area/Main/Exploration">002313</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Magnetic resonance imaging of brain iron in health and disease</title><author><name sortKey="Vymazal, Josef" sort="Vymazal, Josef" uniqKey="Vymazal J" first="Josef" last="Vymazal">Josef Vymazal</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Neuroimaging Branch, National Institute of Neurological Disorders and Stroke. 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Non-heme brain iron is present in the brain mainly in the form of ferritin. The unique magnetic properties of ferritin determine different signal changes on both T1- and T2-weighted images, and the T2 relaxation rates have a linear dependence on applied field strength. This finding is typical for ferric oxyhydroxide cores. The resulting T2-shortening also depends on echo-spacing used in the imaging sequence as well as on the water diffusion coefficient and the size of the ferritin cluster. Quantitation of non-heme brain iron by MRI aids in the diagnosis and monitoring of different neurological diseases.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Vymazal, Josef" sort="Vymazal, Josef" uniqKey="Vymazal J" first="Josef" last="Vymazal">Josef Vymazal</name></region><name sortKey="Brooks, Rodney A" sort="Brooks, Rodney A" uniqKey="Brooks R" first="Rodney A." last="Brooks">Rodney A. Brooks</name><name sortKey="Bulte, Jeff W M" sort="Bulte, Jeff W M" uniqKey="Bulte J" first="Jeff W. M." last="Bulte">Jeff W. M. Bulte</name><name sortKey="Di Chiro, Giovanni" sort="Di Chiro, Giovanni" uniqKey="Di Chiro G" first="Giovanni" last="Di Chiro">Giovanni Di Chiro</name><name sortKey="Hajek, Milan" sort="Hajek, Milan" uniqKey="Hajek M" first="Milan" last="Hajek">Milan Hajek</name><name sortKey="Patronas, Nicholas" sort="Patronas, Nicholas" uniqKey="Patronas N" first="Nicholas" last="Patronas">Nicholas Patronas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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